We diagnosed a patient with chronic dry mouth for 3 years as 'definite Sjogrfen's syndrome' by the criteria for diagnosis of Sjogren's syndrome proposed by the international seminar on Sjogren's syndrome. The clinical, immunologic, hematologic,
scintigraphic, and histopathologic examinations were performed. The patient showed severe xerostomia, keratoconjunctivities sicca, severe infiltration of lymphocytes in minor salivary glands, and evidences of autoantibodies. Preexisting lymphoma,
graft-versus-hors disease, acquired immunodeficiency disease, and sarcoidosis were excluded by the patient's history and clinical findings.
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